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About 85% of the oral dose seems in the urine inside 24 hours of administration, most as being the glucuronide conjugate, with small amounts of other conjugates and unchanged drug (See OVERDOSAGE for toxicity information and facts).

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Abuse and dependancy are separate and distinct from Actual physical dependence and tolerance. Abuse is characterized by misuse on the drug for non-clinical purposes, often together with other psychoactive substances. Bodily dependence is really a point out of adaptation that may be manifested by a selected withdrawal syndrome which can be made by abrupt cessation, swift dose reduction, decreasin g blood level of the drug and/or administration of an antagonist.

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